The Brainport Eindhoven Region hosts the European Commission’s Week of Innovative Regions in Europe (WIRE) from 8 to 10 June 2016. The WIRE 2016 conference provides a platform for policy makers, national and regional authorities, knowledge institutions and enterprises from all over Europe to have an in-depth discussion on research and innovation practices and challenges throughout the European regions, including possibilities in the current EU funding programmes and those beyond 2020. A particular focus lies on extraordinary open innovation practices. In order to create impact, to upscale and aim for global competitiveness, WIRE 2016 intends to increase awareness on the importance and urgent need to build regional innovation ecosystems. The conference is therefore titled: The Power of Regional Innovation Ecosystems.